血管紧张素转换酶基因多态性与早发性糖尿病肾病

目的 探讨血管紧张素转换酶(ACE)基因插入缺失多态性与中国汉族人早发性糖尿痛肾痛之间的关系。方法 应用PCR法检测183例健康对照和132例Ⅱ型糖尿痛伴或不伴肾痛者的ACE基因插入缺失多态性基因型。结果 微量白蛋白尿组和大量白蛋白尿组与正常白蛋白尿组比较，ACE基因I／D多态性等住基因和基因型频率均未见明显差异，正常白蛋白尿组和异常白蛋白尿组之间基因型频率无明显差异，等位基因频率有明显差异，而迟发／未发DN组和早发DN组之间基因型频率和等位基因频率均有显著差异。结论 ACE基因插入缺失多态性与早发性糖尿痛肾病有关。

A Study for ACE Gene Polymorphism in Chinese Type 2 Diabetic Nephropathy

Objective To evaluate the association of early-onset diabetic nephropathy with the insert/delete (I/D) polymorphism of angiotensin-converting enzyme (ACE) gene in Chinese. Methods A case control study was performed on 315 Chinese subjects including 132 type 2 diabetics with or without nephropathy and 183 non-diabetic control. Genotype frequencies of ACE gene polymorphism were studied by PCR method. Results No significant differences were found in genotype frequencies of ACE gene I/D polymorphism between normal and abnormal albuminuria in diabetic patients, but the alleles frequencies were different between them. Moreover, there was obvious difference between early-onset and later-onset diabetic nephropathy in allele and genotype frequencies of ACE gene. Conclusions Our study showed that there was obvious association of ACE I/D polymorphism between early-onset and later-onset diabetic nephropathy in Chinese.