麝香保心丸对缺血性心脏病心功能的影响

目的：研究麝香保心丸（heart-protecting musk pill,HMP）对缺血性心脏病心功能不全的治疗作用.方法：79例缺血性心脏病心功能不全患者随机分为两组.常规治疗（对照组）39例给予地高辛片、血管紧张素转换酶抑制剂或血管紧张素Ⅱ受体拮抗剂、利尿剂等综合治疗;麝香保心丸（HMP）治疗（HMP组）40例,在上述综合治疗基础上加用HMP治疗.两组均3个月为1个疗程.治疗前后测定左室射血分数（EF）、血浆脑钠肽（BNP）、6分钟步行试验（6-MWT）三项指标评定心功能的变化.结果：HMP组EF明显升高,6-MWT距离延长,BNP明显下降,与常规治疗组比较,差异有显著性意义（P＜0.05）.结论：HMP是治疗缺血性心脏病心功能不全的一种有效而安全的药物.

Effect of Heart-protecting Musk Pill on Cardiac Function of Ischemic Heart Disease

Objective:To investigate the effect of heart-protecting musk pill (HMP) on cardiac dysfunction of ischemic heart disease. Methods:79 cases of ischemic heart disease were randomly divided into the contrast group (39 cases) and the HMP group (40 cases). The contrast group was treated by angiotensin-converting enzyme inhibitors, angiotensin II receptorantagonist and diuretics. The HMP group were treated by HMP on the base of normal therapy. Three index including EF, BNP and 6-MWT were observed before and after one treatment course of three months. Results:In the HMP group, EF was improved obviously. The distance of 6-MWT was extended and BNP reduced. The difference between the HMP group and the contrast group had significant meaning (P<0.05). Conclusion:Heart-protecting musk pill is safe and effective to treat the cardiac dysfunction of ischemic heart disease.