蛇毒神经生长因子凝胶对实验动物皮炎的治疗作用

目的：对蛇毒神经生长因子（Nerve growth factor，NGF）凝胶进行了动物实验研究，包括药理学实验，急性毒性实验，皮肤刺激实验和皮肤过敏实验。方法：利用Hartely豚鼠2，4-二硝基氟苯致红斑性皮炎动物模型。结果：NGF凝胶对红斑性皮炎有明显的作用（P〈0．01），超过临床1200倍有效剂量在用药后7天内不能导致皮肤刺激效应和毒性作用。结论：NGF凝胶在治疗皮炎中有显著疗效，无导致全身和局部的不良反应。

The Treatment of Snake Venom Nerve Growth Factor Gel in Experimental Animals' Dermatitis

Objective： To carry out experiment of Nerve Growth Factor gel on animals. Studies included the pharmacological action, the acute toxicologic action, the dermal irritation and dermal hypersensitivity of the ointment. Methods ： Hartely guinea pig 2, 4 - dinitrofluorbenezene （DNFB） allergic contact dermatitis Were used as an animal model, treated with NGF gel. Results： NGF gel had no acute toxicologic action and irritant reaction to skin but had a significant action on dermatitis erythematosa （P 〈 0. 01 ）. 1200 times the clinical efficient dose of NGF gel did not cause any local dermal irritation and toxic effect 7 days after application of the gel. Conclusion： The NGF gel has remarkable the rapeutic effect in treating dermatitis and does not cause any local or systemic adverse reactions.