| 内质网应激与2型糖尿病 |
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| 引用本文： | 傅飞还,陈刚. 内质网应激与2型糖尿病[J]. 医学综述, 2008, 14(3): 424-427 |
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| 作者姓名： | 傅飞还 陈刚 |
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| 作者单位： | 福建中医学院,福建省立医院内分泌科,福州,350001 |
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| 摘 要： | 未折叠或错误折叠蛋白质在内质网腔蓄积及细胞内稳态的破坏将导致内质网应激。适宜的应激有利于细胞内环境的恢复,然而严重而持久的内质网应激反应将导致内质网功能受损,诱导细胞凋亡。β细胞具有高度发达的内质网,是对内质网应激最敏感的细胞之一,内质网应激介导的β细胞凋亡参与了糖尿病的发生。
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| 关 键 词： | 内质网应激 细胞凋亡 糖尿病 |
| 文章编号： | 1006-2084（2008）03-0424-04 |
| 收稿时间： | 2007-08-14 |
| 修稿时间： | 2007-10-29 |
Endoplasmic Reticulum Stress and Type 2 Diabete |
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| FU Fei-huan,CHEN Gang. Endoplasmic Reticulum Stress and Type 2 Diabete[J]. Medical Recapitulate, 2008, 14(3): 424-427 |
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| Authors: | FU Fei-huan CHEN Gang |
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| Affiliation: | FU Fei-huan,CHEN Gang.(Fujian University of Traditional Chinese Medical,Department of Endocrinology,Fujian Provincial Hospital,Fuzhou 350001,China) |
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| Abstract: | Unfolded or misfolded proteins accumulating in endoplasmic reticulum and the disturbance of cells homeostasis will result in the endoplasmic reticulum stress.Endoplasmic reticulum stress to a certain extent lead to the restoration of cells internal environment.However,if the stress is too strong and lasting,the function of endoplasmic reticulum will be damaged and cell apoptosis will present.As one of the most sensitive cells of endoplasmic reticulum stress,pancreatic β-cells have an abundance of endoplasmic reticulum.Apoptosis of insulin-secreting cells induced by endoplasmic reticulum stress participate in the onset of diabete mellitus. |
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| Keywords: | Endoplasmic reticulum stress Cell apoptosis Diabetes mellitus |
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