急性冠脉综合征患者血清C-反应蛋白和血浆D-二聚体的测定及意义

目的:探讨急性冠脉综合征患者血清C-反应蛋白(CRP)和D-二聚体(D-dlimer)的变化及临床意义。方法:选择急性冠脉综合征患者60例,分为AMI组20例,UAP组23例,NQMI组17例,并设SAP组19例,对照组20例。用全自动免疫比浊和酶联免疫吸附法,分别测定血清CRP及血浆D-dimer浓度。结果:急性冠脉综合合征患者血清CRP及血浆D-dimer均高于对照组和SAP组,并有显著性差异(P<0.05,P<0.01),其中AMI组较UAP组和NQMI组升高更明显,但它们比较无显著性差异(P>0.05);SAP组与对照组比较差异无显著性(P>0.05)。结论:急性冠脉综合征患者血清CRP及血浆D-dimer水平明显升高,并与疾病的严重程度密切相关,两者的检测有助于急性冠脉综合征的早期诊断及UAP和SAP的鉴别诊断。

Importance of serum C-reactive protein and plasma D-dimer detection in patients with acute coronary syndrome

Objective: To study the changes and clinical significance of C-reactive protein and D-dimer in patients with acute coronary syndrome . Methods: Acute coronary syndrome patients (60 cases) were divided into acute myocardial infarction(AMI) group (20 cases) , unstable angina pectories(UAP) group 23 cases, non-Q wave myocardial infarction(NQMI) group(17 cases), Stable angina pectories(SAP) group(19 cases) and control group (20 cases)were included for comparison. Serum C-creative protein and plasma D-dimer were tested by photometry immune-turbidimetric test and enzyme linked immunosorbent assay respectively. Results : the level of serum C-reactive protein and plasma D-dimer in patients with acute coronary syndrome were higher than that of SAP and Control group , and the change was significant(P<0.05,P<0.01),test results of AMI group were higher than that of UAP and NQMI group ,but change between them was not significant(P>0.05); Compared with control ,change of SAP group was no significant(P>0.05). Conclusion: level of C-reactive protein and D-dimer in acute coronary syndrome becomes higher ,and is associated with the degree of disease , both tests are helpful to early diagnosis of acute coronary syndrome and distinctive diagnosis between UAP and SAP.