Special delivery: granulin brings CpG DNA to Toll-like receptor 9 |
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| Authors: | Moresco Eva Marie Y Beutler Bruce |
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| Affiliation: | Department of Genetics, The Scripps Research Institute, 10550 N. Torrey Pines Road, La Jolla, CA 92037, USA. |
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| Abstract: | Foreign DNA activates the innate immune response through Toll-like receptor 9 (TLR9). In this issue of Immunity, Park et?al. (2011) present evidence that granulin is a cofactor for TLR9 activation, delivering CpG-oligodeoxynucleotides to TLR9 in endolysosomes. |
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