类风湿关节炎相关肺间质病变的危险因素分析

目的 分析类风湿关节炎（RA）相关肺间质病变（RA-ILD）的临床及实验室指标,探讨其发病的危险因素.方法 回顾性分析150例住院诊治的RA患者的临床及实验室资料,根据HRCT结果分为单纯RA组126例和RA-ILD组24例,比较两组患者的相关资料.结果 RA-ILD组患者在年龄、病程、吸烟率、疾病活动度及类风湿因子及抗环瓜氨酸肽抗体值均高于单纯RA组,差异有统计学意义（P＜0.05）.结论 年龄大,病程长,男性,吸烟史,RF及抗CCP高滴度表达,高疾病活动度的RA患者易合并ILD,应尽早行HRCT等检查,以早期诊断及治疗.

Analysis of risk factors in patients with rheumatoid arthritis associated interstitial lung disease

Objective To analyze the clinical features and laboratory data of rheumatoid arthritis （RA） patients with and without interstitial lung disease （ILD） and investigate the associated risk factors.Methods 150 RA patients were divided into RA group （n=126） and RA-ILD group （n=24）.The general state of health,clinical manifestations and levels of serum markers were compared between the two groups.Results RA-ILD was associated with older age at the time of disease onset,longer disease duration,smoking,higher disease activity scores,higher level of serum rheumatoid factor （RF） and anti-citrullinated peptide/protein antibodies （anti-CCP） （all P〈0.05）.Conclusion Chest HRCT should be taken to get early diagnosis and treatment of ILD in patients with RA,especially in the elder patients with high titer of RF and anti-CCP,severer disease.