| 神经末端B型脑钠肽原的检测在老年慢性心力衰竭诊断中的应用 |
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| 引用本文： | 刘永梅,申小梅,张向君,田立成,刘文阁,刘希云.神经末端B型脑钠肽原的检测在老年慢性心力衰竭诊断中的应用[J].西部医学,2014(3):308-309,313. |
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| 作者姓名： | 刘永梅 申小梅 张向君 田立成 刘文阁 刘希云 |
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| 作者单位： | 昌黎县人民医院,河北昌黎066600 |
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| 基金项目： | 秦皇岛市科研基金项目（2012023A236） |
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| 摘 要： | 目的观察老年慢性心力衰竭患者血浆中N末端B型脑钠肽原（NT-proBNP）的浓度变化。方法选择心功能Ⅱ-Ⅳ级老年慢性心力衰竭患者120例作为观察组，选择正常体检老年人110例作为对照组。用德国进口技术的POCT仪器测量所有患者的血浆NT-proBNP浓度，并根据实际情况进行纽约心脏病协会（NYHA）心功能分级。结果老年慢性心力衰竭组的NT-proBNP较对照组明显升高，且随着心功能分级的升高NT-proBNP逐渐增加，差异有统计学意义（P〈0．05）。结论检测血浆NT-proBNP是诊断老年慢性心力衰竭的可靠化验指标。并且与心功能的严重程度关系密切。动态监测老年慢性心力衰竭患者血浆NT-proBNP的变化可有效评估患者的预后。
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| 关 键 词： | N末端B型脑钠肽原 老年人 慢性心力衰竭 |
NT-proBNP peptide in elderly patients with chronic heart failure |
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| Institution: | LIU Yong-mei, SHEN Xiao-mei, ZHANG Xiang-jun, et al (Changli People ＇ s Hospital, Changli 066600, Hebei) |
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| Abstract: | Objective To observe N-terminal B-type natriuretic peptide （NT-proBNP） in elderly patients with chronic heart failure. Methods 120 patients with chronic heart failure class Ⅱ-Ⅳ were selected as the observation group and controlled with 110 people with physical examination. The serum NT-proBNP was detected with Germany imported technology POCT instruments. The heart function was classified with New York Heart Association （NYHA） Heart As- sociation functional class. Results The NT-proBNP of elderly patients with chronic heart failure was significantly higher than that of the control group（P〈0.05）. Conclusion Detection of plasma NT-proBNP is a reliable indicator for the di- agnosis of chronic heart failure, and is closely related to the severity of heart failure. Dynamic observation of plasma NT- proBNP level changes can effectively determine the prognosis of patients. |
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| Keywords: | N-terminal B-type brain natriuretic peptide Old ages Chronic heart failure |
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