An Observational Real-Life Study with a New Infant Formula in Infants with Functional Gastro-Intestinal Disorders |
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| Authors: | Yvan Vandenplas Laetitia Gerlier Karin Caekelbergh Nan-Study-Group Mike Possner |
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| Affiliation: | 1.KidZ Health Castle, Vrije Universiteit Brussel (VUB), UZ Brussel, 1090 Brussels, Belgium;2.IQVIA, 1930 Zaventem, Belgium; (L.G.); (K.C.);3.Nestlé Nutrition Institute, 60528 Frankfurt am Main, Germany; |
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| Abstract: | Functional gastro-intestinal disorders (FGIDs) impair the quality of life of many infants and their families. A formula with partial whey hydrolysate, starch, high magnesium content, prebiotic fructo-oligosaccharide and galacto-oligosaccharide and the probiotic Lactobacillus reuteri DSM 17938 was given during two weeks to 196 infants with at least two FGIDs. The efficacy was evaluated with the Cow Milk-associated Symptom Score (CoMiSS®) and quality of life with the QUALIN score. The formula was shown to decrease FGIDs within three days (decrease of CoMiSS −1.29 (3.15) (mean (SD), p < 0.0001) followed by an improvement of quality of life after seven days (increase QUALIN +1.4 (7.8); p: 0.008). Constipation decreased from 18.8% to 6.5% within three days. In combination with reassurance and guidance, the nutritional intervention was shown to be effective in infants with FGIDS in real-life circumstances. |
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| Keywords: | constipation colic CoMiSS crying functional gastro-intestinal disorder gastro-esophageal reflux regurgitation QUALIN quality of life |
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