| CD8+T细胞耗竭发生和特征及其与肿瘤免疫治疗耐药的研究进展 |
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| 引用本文： | 庞博月, 王晶, 韩颖. CD8+T细胞耗竭发生和特征及其与肿瘤免疫治疗耐药的研究进展[J]. 中国肿瘤临床, 2023, 50(23): 1217-1220. DOI: 10.12354/j.issn.1000-8179.2023.20231027 |
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| 作者姓名： | 庞博月 王晶 韩颖 |
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| 作者单位： | 1.天津医科大学肿瘤医院生物治疗科，国家恶性肿瘤临床医学研究中心，天津市“肿瘤防治”重点实验室，天津市恶性肿瘤临床医学研究中心，天津市肿瘤免疫与生物治疗重点实验室（天津市300060） |
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| 基金项目： | 国家自然科学基金项目（编号：81702268）；;天津市自然科学基金项目（编号：18JCYBJC93400）资助~~； |
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| 摘 要： | 免疫检查点抑制剂（immune checkpoint inhibitors，ICIs）是治疗多种肿瘤的重要手段，但耐药成为其最大难题。肿瘤免疫治疗耐药与肿瘤微环境（tumor microenvironment，TME）密切相关，TME中CD8+T细胞耗竭不仅持续性高表达抑制性受体（inhibitory receptors，IRs），同时也是导致ICIs耐药的关键环节，靶向IRs为克服免疫治疗耐药提供了新思路。本文将重点对CD8+T细胞耗竭发生和特征及其与肿瘤免疫治疗耐药性相关的研究进行综述。
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| 关 键 词： | 免疫治疗 免疫检查点抑制剂 CD8+T细胞耗竭 耐药 肿瘤微环境 |
| 收稿时间： | 2023-10-18 |
| 修稿时间： | 2023-12-01 |
Mechanisms of CD8+ T cell exclusion and dysfunction in cancer resistance to anti-PD-(L)1 |
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| Boyue Pang, Jing Wang, Ying Han. Research progress on the occurrence and characteristics of CD8+T cell exhaustion and its relationship with tumor immunotherapy resistance[J]. CHINESE JOURNAL OF CLINICAL ONCOLOGY, 2023, 50(23): 1217-1220. DOI: 10.12354/j.issn.1000-8179.2023.20231027 |
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| Authors: | Boyue Pang Jing Wang Ying Han |
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| Affiliation: | 1.Department of Biotherapy, Tianjin Medical University Cancer Institute & Hospital, National Clinical Research Center for Cancer, Tianjin Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Tianjin Key Laboratory of Cancer Immunology and Biotherapy, Tianjin 300060, China |
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| Abstract: | Immune checkpoint inhibitors (ICIs) have emerged as important targets of treatment for various types of cancers, yet drug resistance poses considerable problems. Tumor immunotherapy resistance is closely related to the tumor microenvironment (TME). Exhaustion of CD8+T cells in the TME continuously express high levels of inhibitory receptors (IRs) and play a central role in ICIs resistance. Targeting IRs provides new prospects for overcoming immunotherapy resistance. This review focuses on the occurrence and characteristics of CD8+T cell exhaustion and explores its association with tumor immunotherapy resistance. |
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| Keywords: | immunotherapy immune checkpoint inhibitors (ICIs) CD8+T cell exhaustion drug resistance tumor microenvironment (TME) |
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