Proinflammatory cytokines detectable in synovial fluids from patients with temporomandibular disorders |
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| Institution: | 1. Division of Oral and Maxillofacial Surgery, Akita University School of Medicine. Akita, Japan;2. Department of Oral and Maxillofacial Surgery, Yokohama Rosai Hospital. Yokohama, Japan;3. Division of Oral and Maxillofacial Surgery, Akita University School of Medicine. Akita, Japan;4. Division of Oral and Maxillofacial Surgery, Akita University School of Medicine. Akita, Japan;5. Department of Immunology and Bioregulation, Shionogi Research Laboratories, Shionogi & Co., Ltd. Osaka, Japan;6. Department of Immunology and Bioregulation, Shionogi Research Laboratories, Shionogi & Co., Ltd. Osaka, Japan;1. Department of Physics, University of Helsinki, Helsinki, Finland;2. Department of Oral and Maxillofacial Surgery/Oral Pathology, VU University Medical Center, Amsterdam, The Netherlands;3. Department of Radiology, Medical Imaging Center, Tampere University Hospital, Tampere, Finland;4. University of Tampere Medical School, Tampere, Finland;5. HUS Medical Imaging Center, University of Helsinki, Helsinki, Finland;1. Department of Radiation Oncology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania;2. Department of Biostatistics and Epidemiology, University of Pennsylvania, Philadelphia, Pennsylvania;3. Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania;4. Department of Radiation Oncology, University of Michigan, Ann Arbor, Michigan;5. Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, New York;6. Emory University School of Medicine, Emory University, Atlanta, Georgia;7. Department of Pediatrics, Children''s Hospital of Philadelphia, University of Pennsylvania, Philadelphia, Pennsylvania;8. Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University, Baltimore, Maryland;1. Harvard-MIT Division of Health Sciences and Technology, Harvard Medical School, Boston, MA;2. Harvard Medical School, Boston, MA;3. Harvard T.H. Chan School of Public Health, Boston, MA;4. Department of Radiation Oncology, Dana-Farber Cancer Institute and Brigham and Women’s Hospital, Boston, MA;5. Department of Medical Oncology, Dana-Farber Cancer Institute and Brigham and Women’s Hospital, Harvard Medical School, Boston, MA;6. Department of Radiation Oncology, MD Anderson Cancer Center, Houston, TX;7. Department of Urology, Brigham and Women’s Hospital, Boston, MA;1. The Affiliated Hospital of Nanjing University of TCM, Jiangsu Province Hospital of TCM, Nanjing, PR China;2. No. 1 Clinical Medical College, Nanjing University of Chinese Medicine, Nanjing, Jiangsu, PR China |
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| Abstract: | Objective. To measure the levels of the proinflammatory cytokines, interleukin (IL)-1β, IL-6, tumor necrosis factor- (TNF)α, IL-8, and interferon- (IFN) γ in synovial fluid samples taken from patients with temporomandibular disorders (TMD).Study design. We studied 6 asymptomatic volunteers and 51 patients with TMD. The IL-1β, IL-6, TNF-α, IL-8, and IFN-γ levels in temporomandibular joint synovial fluid were measured using enzyme-linked immunosorbent assay.Results. Measurable level of at least one cytokine in the synovial fluid was found in 40 (64.5%) of 62 joints in the patients: IL-1β and IFN-γ were each detected in 18 (29.0%) of 62 joints; IL-6 in 13 (21.0%) of 62 joints; IL-8 in 11 (19.3%) of 57 joints; and TNF-α in only 5 (8.1%) of 62 joints. None of these cytokines was detectable in the synovial fluid in the control group. Furthermore, there was a strong correlation between the detection of IL-1β and pain in the joint area.Conclusions. These data clearly demonstrate increased levels of several proinflammatory cytokines in certain patients with TMD and suggest that these cytokines may play a role in the pathogenesis of synovitis and degenerative changes of the cartilaginous tissue and bone of the temporomandibular joint. |
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