PS8812多糖及其硒多糖抗诱变试验 |
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引用本文: | 张全新,聂木海. PS8812多糖及其硒多糖抗诱变试验[J]. 癌变.畸变.突变, 2004, 16(1): 43-46 |
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作者姓名: | 张全新 聂木海 |
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作者单位: | 广州市疾病预防控制中心毒理科,广东,广州,510080;广州市疾病预防控制中心毒理科,广东,广州,510080 |
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摘 要: | 背景与目的:探讨PS8812多糖及其硒多糖的抗诱变作用.材料与方法:采用Ames试验、小鼠骨髓微核及小鼠精子畸形抗突变试验.结果:多糖和硒多糖对鼠伤寒沙门氏菌突变菌株TA98及TA100的回复突变有明显抑制作用,最高抑制率分别为65.39%和73.21%;多糖和硒多糖也能显著降低环磷酰胺诱导的微核率和精子畸形率,微核抑制率为40.24%~60.37%,精子畸形抑制率为38.92%~62.36%.结论:PS8812多糖及其硒多糖均有明显的抗诱变作用.
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关 键 词: | 多糖 硒多糖 抗诱变性 |
文章编号: | 1004-616X(2004)01-0043-04 |
修稿时间: | 2003-03-03 |
Anti- mutagenicity test of PS8812 Polysaccharides and its Selenium Polysaccharides |
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Abstract: | BACKGROUND & AIM:To study the antimutagenic effect of PS8812 Polysaccharides (PSP) and its Selenium Polysaccharides(PSSP) .MATERIAL AND METHODS: The Ames test, mouse marrow micronueleus test and mouse sperm malformation test were used. RESULTS: PSP and PSSP both could evidently inhibit the reverse mutation on Salmonella thphimurium strains TA98 and TA100 with and without S9 mix. The rates of maximum inhibition were 65.39 % and 73.21 % respectively. The frequencies of micronueleus and abnormal sperms induced by cyclophosphamide (CP)were reduced significantly by PSP and PSSP. The inhibitory rate of micronueleus was between 40.24% and 60. 37%; the inhibitory rate of abnormal sperms was between 38.92 % and 62.36 % .CONCLUSION: PSP and PSSP have significant antimutagenic effect. |
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Keywords: | polysa ccharides selenium polysaccharides ant- imutagenicity |
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