| 联合应用卷曲霉素治疗耐多药肺结核268例的疗效观察 |
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| 引用本文： | 刘廷辉,刘伟.联合应用卷曲霉素治疗耐多药肺结核268例的疗效观察[J].中国药房,2005,16(22):1727-1728. |
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| 作者姓名： | 刘廷辉 刘伟 |
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| 作者单位： | 1. 沈阳市胸科医院,沈阳市,110044
2. 沈阳市第十人民医院,沈阳市,110044 |
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| 摘 要： | 目的:观察联合应用卷曲霉素治疗耐多药肺结核的疗效。方法:268例耐多药肺结核患者先采用左氧氟沙星、吡嗪酰胺、结核清、丙硫异烟胺和卷曲霉素强化治疗3mo,再用左氧氟沙星、结核清和丙硫异烟胺巩固治疗9mo。结果:痰菌转阴率高达78.36%,空洞闭合率达37.76%。结论:全程贯彻直接监督化疗原则,选用卷曲霉素等对结核分枝杆菌敏感的药物组合,可提高耐多药肺结核的疗效。
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| 关 键 词： | 卷曲霉素 耐多药结核病 直接监督化疗 |
| 文章编号： | 1001-0408（2005）22-1727-02 |
| 收稿时间： | 2005-09-09 |
| 修稿时间： | 2005-10-06 |
Observation on Therapeutic Effect of Combined Use of Capreomycin in Treating 268 Patients with Multiple - drug - resistant Tuberculosis |
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| LIU Tinghui,LIU Wei.Observation on Therapeutic Effect of Combined Use of Capreomycin in Treating 268 Patients with Multiple - drug - resistant Tuberculosis[J].China Pharmacy,2005,16(22):1727-1728. |
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| Authors: | LIU Tinghui LIU Wei |
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| Institution: | 1.The Pectoral Disease Hospital of Shanyang,Shenyang 110044,China;2. No. 10 Hospital of Shenyang, Shenyang 110044, China |
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| Abstract: | OBJECTIVE:To observe the therapeutic effect of combined use of capreomycin in treating multiple-drug-resistant tuberculosis.METHODS:After 268 patients with multiple-drug-resistant tuberculosis had underwent intensive treatment with levofloxacin,pyrazinamide,pasiniazid,protioamide and capreomycin for 3 months,they underwent another 9 months of strengthened treatment with levofloxacin,pasiniazid,and rotioamide.RESULTS:The negative rate determined in sputum test for tuberculosis bacteria was up to 78.36%,and the closing rate of the cavity was up to 37.76%.CONCLUSION:The therapeutic effect for treatment of multiple-drug-resistant tuberculosis can be improved by carrying out the principle of whole range direct monitoring of chemotherapy and using capreomycin in combination with other drugs to increase the sensitivity to mycobacterium tuberculosis. |
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| Keywords: | Capreomycin Multiple-drug-resistant tuberculosis Direct monitoring of chemotherapy |
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