Behavioral, electrophysiological, and histopathological consequences of mild fluid-percussion injury in the rat |
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Authors: | Sanders M J Dietrich W D Green E J |
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Institution: | Munchner Technologiezentrum, IDEA-AG, Frankfurter Ring 193a, 80087, Munich, Germany. |
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Abstract: | We investigated in rats the effect N(G)-nitro-L-arginine methyl ester (L-NAME) on retention of a passive avoidance response, and cortical ACh release monitored using the microdialysis technique. Post-training administration of L-NAME impaired 24 h retention of a passive avoidance and decreased cortical ACh release. Both effects of L-NAME were reversed by L-Arg. These results suggest that nitric oxide is involved in retention of the passive avoidance response through the modulation of the forebrain cholinergic system. |
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Keywords: | Acetylcholine Memory Microdialysis Nitric oxide Passive avoidance |
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