Developmental stability of taurine's activation on glycine receptors in cultured neurons of rat auditory cortex |
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Authors: | Tang Zheng-Quan Lu Yun-Gang Chen Lin |
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Institution: | Hefei National Laboratory for Physical Sciences at Microscale and School of Life Sciences, University of Science and Technology of China, Hefei 230027, China. |
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Abstract: | Taurine is an endogenous amino acid that can activate glycine and/or gamma-aminobutyric acid type A (GABA(A)) receptors in the central nervous system. During natural development, taurine's receptor target undergoes a shift from glycine receptors to GABA(A) receptors in cortical neurons. Here, we demonstrate that taurine's receptor target in cortical neurons remains stable during in vitro development. With whole-cell patch-clamp recordings, we found that taurine always activated glycine receptors, rather than GABA(A) receptors, in neurons of rat auditory cortex cultured for 5-22 days. Our results suggest that the functional sensitivity of glycine and GABA(A) receptors to taurine is critically regulated by their developmental environments. |
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Keywords: | Taurine Glycine receptor γ-Aminobutyric acid type A receptor Auditory cortex Cell culture Whole-cell patch–clamp Development |
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