奥美拉唑、左氧氟沙星、阿莫西林三联疗法根除消化性溃疡患者幽门螺杆菌的疗效观察

目的探讨奥美拉唑、左氧氟沙星、阿莫西林三联疗法在幽门螺杆菌阳性的消化性溃疡患者中的疗效。方法将360例幽门螺杆菌阳性的消化性溃疡患者随机分为治疗组174例和对照组186例。治疗组给予奥美拉唑20mg,每天2次;左氧氟沙星片0.2g,每天2次;阿莫西林胶囊1.0g,每天2次,疗程为10d。对照组给予奥美拉唑20mg,每天2次;克拉霉素分散片0.2g,每天2次;阿莫西林胶囊1.0g,每天2次,疗程为10d。治疗后比较2组幽门螺杆菌根除率。结果治疗组十二指肠溃疡、胃溃疡及复合性溃疡患者幽门螺杆菌根除率均高于对照组(P<0.05)。不良反应轻微。结论奥美拉唑、左氧氟沙星、阿莫西林三联疗法对根除消化性溃疡患者幽门螺杆菌效果好,安全性好。

Effect observation of omeprazole,levofloxacin and amoxicillin in patients with peptic ulcer to eradicate H.pylori

Objective To explore the effect of omeprazole,levofloxacin and amoxicillin in patients with peptic ulcer to eradicate H.pylori.Methods 360 cases patients with peptic ulcer were randomly divided into treatment group（174 cases） and control group（186 cases）.Treatment group received omeprazole 20mg,2 times a day;Levofloxacin 0.2g,2 times a day;Amoxicillin 1.0g,2 times a day,course of treatment for 10d.Control group received omeprazole 20mg,2 times a day;Clarithromycin tablet 0.2g,2 times a day;Amoxicillin 1.0g,2 times a day,course of treatment for 10d.After treatment,compared H.pylori eradication rate of 2 groups.Results The H.pylori eradication rate of patients with duodenal ulcer,gastric ulcer and complex ulcer in treatment group were markedly higher than those of control group（P0.05）.Conclusion Omeprazole,levofloxacin and amoxicillin in patients with peptic ulcer to eradicate H.pylori are effective and safe.