糖尿病肾病的临床与限蛋白饮食干预

糖尿病肾病（DN）是终末期肾衰及糖尿病（DM）死亡的重要原因。早期肾小球滤过率（GFR）和尿白蛋白排泄率（UAE）增加，临床以蛋白尿为主要特征；晚期GFR下降，出现低蛋白血症，贫血，浮肿，高血压等症。目前尚缺乏有效的治疗方法，近来国外一些学者提出，早期进行饮食干预，即糖尿病一经诊断就给予限蛋白饮食（低蛋白和植物蛋白摄入），将有助于降低GFR，阻止肾脏损害，逆转病情，防治DN，不失为一种重要的治疗手段。

Interference of dietary protein restriction and clinic of diabetic nephropathy

Diabetic nephropathy (DN) is an important factor of fatality in patients with diabetes mellitus (DM) and terminal renal failure. In the early stage, DN has an elevation of glomerular filtration rate (GFR) and urinary albumin excretion rate (UAE), the clinical feature mainly is proteinuria. In the late stage, GFR decreases, and hypoproteinemia, anemia, edema and hypertension may present. This entity is lack of effective treatment. Recent studies showed that diet interference by moderate proteins (low animal and vegetable protein) had an effect on decreasing GFR and reversing the state of illness.Dietary protein restriction might be an important measure to prevent and treat DN.