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| 顶空气相色谱法测定布洛芬中残留乙醇、1,2-二氯乙烷 | |
| 引用本文： | 邢玉君,赵培新,王梅,白秀萍.顶空气相色谱法测定布洛芬中残留乙醇、1,2-二氯乙烷[J].齐鲁药事,2005,24(5):286-288. |
| 作者姓名： | 邢玉君 赵培新 王梅 白秀萍 |
| 作者单位： | 1. 淄博医药采购供应站,淄博,255030 2. 山东新华制药有限公司,淄博,255000 3. 淄博市药品检验所,淄博,255040 |
| 摘 要： | 目的建立布洛芬中残留乙醇和1,2-二氯乙烷的顶空进样气相色谱法测定方法。方法色谱柱为HP-624(长30m,内径为0.53mm,膜厚3.0μm,固定液为6%-氰丙基苯基聚硅氧烷-94%-二甲基聚硅氧烷)。氢火焰离子化检测器,检测器温度为260℃,进样口温度140℃。结果乙醇的线性范围为5.0～603.6μg,r=0.9996,回收率为95.2%,RSD=2.4%(n=6)。1,2-二氯乙烷的线性范围为0.026～5.2μg,r=0.99999,回收率为101.4%,RSD=3.9%(n=6)。乙醇与1,2-二氯乙烷之间的分离度为R=18.8。结论该方法简单、准确。 |
| 关 键 词： | 气相色谱 布洛芬 乙醇 1 2-二氯乙烷 |
| 文章编号： | 1672-7738(2005)05-0286-03 |
Determination of alcohol and 1,2-dichloroethane in Ibuprofen by head-space GC method |
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| Xing Yu-jun,Zhao Pei-xin,Wang Mei,BAI Xiu-ping.Determination of alcohol and 1,2-dichloroethane in Ibuprofen by head-space GC method[J].qilu pharmaceutical affairs,2005,24(5):286-288. | |
| Authors: | Xing Yu-jun Zhao Pei-xin Wang Mei BAI Xiu-ping |
| Institution: | Xing Yu-jun,Zhao Pei-xin1,Wang Mei2,Bai Xiu-ping2 |
| Abstract: | Objective A head-space GC method for determination of alcohol and 1,2-dichloroethane in Ibuprofen was established.Methods HP-624 column(6%-cyanopropylphenyl-94%-dimethylpolysiloxane stationary phase,length 30m,I.D.0.53mm,film 3.0μm) was used.Flame-ionization detector temperature was 260℃ and injection port temperature was 140℃.Results The linear range of alcohol was 5.0～603.6μg,r=0.9996.The recovery rate of alcohol was 95.2%,RSD=2.4%(n=6).The linear range of 1,2-dichloroethane was 0.026～5.2μg,r=0.9999.The recovery rate of 1,2-dichloroethane was 101.4%,RSD=3.9%(n=6).The resolution between alcohol peak and 1,2-dichloroethane peak was 18.8.Conclusion The method was simple and accurate. |
| Keywords: | GC Ibuprofen alcohol 1 2-dichloroethane |
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