| Fas/FasL在牙髓炎症过程中的分布及意义 |
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| 引用本文： | 余擎,吴补领,肖明振,王宁. Fas/FasL在牙髓炎症过程中的分布及意义[J]. 实用口腔医学杂志, 2002, 18(4): 307-309 |
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| 作者姓名： | 余擎 吴补领 肖明振 王宁 |
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| 作者单位： | 1. 西安第四军医大学口腔医学院牙体病科,710032
2. 西安电力中心医院口腔科 |
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| 摘 要： | 目的：观察Fas/FasL基因及其蛋白在正常牙髓和炎症牙髓中的表达和分布，探讨其在牙髓炎症过程中的作用机制。方法：采用免疫组织化学染色及原位杂交方法。结果：正常牙髓组织中Fas表达量不高，FasL呈阴性表达，而在牙髓炎症过程中两者均有阳性表达，且其组织细胞的分布与TUNEL法的结果相似。结论：牙髓炎症过程中的细胞凋亡可能是通过Fas介导的LPS等一些因素可能使牙髓组织细胞膜上的Fas和FasL的表达量增加，从而通过其介导的信号转导途径引起细胞凋亡。
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| 关 键 词： | 基因表达 牙髓炎 原位杂交 细胞凋亡 Fas FasL 免疫组织化学 作用机制 |
| 文章编号： | 1001-3733(2002)-04-0307-03 |
| 修稿时间： | 2001-10-21 |
The significance of Fas and FasL expression in pulpitis |
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| Yu Qing,Wu Buling,Xiao Mingzhen,et al.. The significance of Fas and FasL expression in pulpitis[J]. Journal of Practical Stomatology, 2002, 18(4): 307-309 |
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| Authors: | Yu Qing Wu Buling Xiao Mingzhen et al. |
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| Affiliation: | Yu Qing,Wu Buling,Xiao Mingzhen,et al. Department of Oral Conservation,College of Stomatology,Fourth Military Medical University,Xi'an 710032 |
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| Abstract: | Objective: To study the role of Fas/FasL signal in pulpitis. Methods: The expression of Fas/FasL in rat normal and inflammatory dental pulp was observed by immunohistochemical method and the expression of fas mRNA was studied by in situ hybridization. Results: A few of Fas and few of FasL positive cells were observed in normal dental pulp, while in inflammatory dental pulp many polymorphonuelear neutrophyl leukocytes(PMNs) and some pulp cells in the inflammatory area were stained positive. Conclusion: The apoptosis in dental pulp induced by Fas/FasL may play a role in pulpitis. |
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| Keywords: | Gene expression Pulpitis Hybridlzation in sita Apoptosis |
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