A study on motility of sphincter of Oddi in postcholecystectomy syndrome

Endoscop c manometry of sphincter of Oddi(SO)and serumlevels of gastrin,glucagon,and somatostatin were measured in patients withpostcholecystectomy syndrome(n=12),asymptomatic cholecystectomised pa-tients(n=6),and controlled subjects(n=14).Pentagastrin-stimulated gastricacid secretion test was also performed in part of patients who had symptoms orno symptoms after gallbladder resection.The results showed that the patientsof symptomatic group had hypertonic dyskinesia of SO as shown by deep andwide waves superimposed on high basal pressure plateau of SO.The symptoma-tic group also had a higher serum level of gastrin and a greater BAO than tho-se of other two groups.No difference of serum levels of glucagon and soma-tostatin was found among these three groups.The hypertonic dyskinesia of SOand hypergastrinemia are considered as possibly important factors in the patho-genesis of postcholecystectomy syndrome.

A study on motility of sphincter of Oddi in postcholecystectomy syndrome

Endoscop c manometry of sphincter of Oddi(SO)and serum levels of gastrin,glucagon,and somatostatin were measured in patients with postcholecystectomy syndrome(n=12),asymptomatic cholecystectomised pa- tients(n=6),and controlled subjects(n=14).Pentagastrin-stimulated gastric acid secretion test was also performed in part of patients who had symptoms or no symptoms after gallbladder resection.The results showed that the patients of symptomatic group had hypertonic dyskinesia of SO as shown by deep and wide waves superimposed on high basal pressure plateau of SO.The symptoma- tic group also had a higher serum level of gastrin and a greater BAO than tho- se of other two groups.No difference of serum levels of glucagon and soma- tostatin was found among these three groups.The hypertonic dyskinesia of SO and hypergastrinemia are considered as possibly important factors in the patho- genesis of postcholecystectomy syndrome.