| 乳腺导管不同类型增生性病变中p63和CK5/6的表达及意义 |
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| 引用本文： | 梁鑫,黄受方,周小鸽. 乳腺导管不同类型增生性病变中p63和CK5/6的表达及意义[J]. 国际病理科学与临床杂志, 2010, 30(1): 20-26. DOI: 10.3969/j.issn.1673-2588.2010.01.004 |
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| 作者姓名： | 梁鑫 黄受方 周小鸽 |
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| 作者单位： | 1. 附属北京妇产医院,病理科,北京,100006
2. 附属友谊医院,病理科,北京,100050 |
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| 摘 要： | 目的：明确不同类型的乳腺导管增生性病变中p63和Cytokeratin 5/6(CK5/6)的表达和意义。方法：对150例乳腺导管增生性病变中的368个病灶分别进行p63和CK5/6染色。结果：CK5/6在正常乳腺组织中的肌上皮和导管上皮均阳性表达,35例普通型增生中,33例CK5/6呈马赛克式阳性表达,仅2例弥漫阳性;在非典型性增生、原位癌和浸润癌中,CK5/6主要呈阴性表达,仅6例阳性,其中有2例雌激素受体（estrogen receptor, ER）、孕激素受体（progesterone receptor, PR）和CerbB 2阴性,符合基底细胞样癌的特点。p63在良性病变和非浸润性肿瘤性增生病变中的肌上皮细胞阳性表达,3例原位癌不表达p63和CK5/6。浸润癌中有3例（3/43）p63散在肿瘤细胞阳性,其余均阴性。结论：不同类型乳腺增生性病变中p63及CK5/6的染色模式存在一定规律,有助于这些病变的诊断和鉴别诊断。
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| 关 键 词： | 乳腺 导管病变 增生性病变 p63 CK5/6 |
| 收稿时间： | 2009-11-13 |
| 修稿时间： | 2009-12-30 |
Expression of p63 and CK5/6 in different breast intraductal proliferative lesions and its significance in the diagnosis |
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| LIANG Xin,HUANG Shoufang,ZHOU Xiaoge. Expression of p63 and CK5/6 in different breast intraductal proliferative lesions and its significance in the diagnosis[J]. Journal of International Pathology and Clinical Medicine, 2010, 30(1): 20-26. DOI: 10.3969/j.issn.1673-2588.2010.01.004 |
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| Authors: | LIANG Xin HUANG Shoufang ZHOU Xiaoge |
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| Affiliation: | LIANG Xin1,HUANG Shoufang2,ZHOU Xiaoge2(1.Department of Pathology,Beijing Obstetrics , Gynecology Hospital,Capital Medical University,Beijing 100006,2.Department of Pathology,Beijing Friendship Hospital,Beijing 100050,China) |
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| Abstract: | Objective To determine the expression of p63 and CK5/6 in different breast intraductal proliferative lesions and its significance in the diagnosis.Methods The expression of p63 and CK5/6 in 368 breast lesions from 150 samples was analyzed by immunohistochemical staining.Results In the normal breast tissues,the expression of CK5/6 existed in myoepithelial and luminal epithelial cells.Among the 35 general proliferative lesions,33 of CK5/6 staining showed mosaic pattern and 2 displayed diffuse positive pattern... |
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| Keywords: | breast ductal lesion hyperplasia lesion p63 ck5/6 |
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