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Spatial and chronological differences in hepatitis B virus genotypes from patients with acute hepatitis B in Japan |
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| Authors: | Fuminaka Sugauchi Etsuro Orito Tomoyoshi Ohno Yasuhito Tanaka Jong-Hon Kang Tomoyuki Kuramitsu Eiji Tanaka Takafumi Ichida Kazuaki Inoue Shiro Iino Shinichi Kakumu Takeshi Okanoue Yoshikazu Murawaki Morikazu Onji Michio Sata Ryuzo Ueda |
| Affiliation: | a Department of Clinical Molecular Informative Medicine, Nagoya City University Graduate School of Medical Sciences, Kawasumi, Mizuho, Nagoya 467-8601, Japan b Department of Internal Medicine and Molecular Science, Nagoya City University Graduate School of Medical Sciences, Kawasumi, Mizuho, Nagoya 467-8601, Japan c Teinekeijinkai Hospital, Sappolo, Japan d Sapporo Kosei General Hospital, Sappro, Japan e Akita City Hospital, Akita, Japan f Iwate Medical University, Morioka, Japan g Shinshu University Graduate School of Medicine, Matsumoto, Japan h University of Yamanashi, Yamanashi, Japan i Department of Gastroenterology, Juntendo University School of Medicine, Shizuoka Hospital, Shizuoka, Japan j Musashino Red Cross Hospital, Tokyo, Japan k Showa University Fujigaoka Hospital, Yokohama, Japan l Hepaptitis Research Institute, Tokorozawa, Japan m Kiyokawa Hospital, Tokyo, Japan n St. Marianna University School of Medicine, Kawasaki, Japan o Aichi Medical University School of Medicine, Aichi, Japan p Gifu Municipal Hospital, Gifu, Japan q Kyoto Prefectural University of Medicine, Kyoto, Japan r Osaka City University, Osaka, Japan s Tottori University, Tottori, Japan t Yamaguchi University School of Medicine, Yamaguchi, Japan u Ehime University School of Medicine, Matsuyama, Japan v National Hospital Organization Nagasaki Medical Center, Nagasaki, Japan w Kurume University School of Medicine, Kurume, Japan x Miyakawa Memorial Reserch Foundation, Tokyo, Japan |
| Abstract: | Genotypes of hepatitis B virus (HBV) were determined in 485 patients with acute hepatitis B from all over Japan. They were A in 92 (19%), Ba in 26 (5%), Bj in 32 (7%), C in 330 (68%) and D in 5 (1%). Sexual contacts were the main route of transmission in them. Overall, HBV persisted in only 5 of the 464 (1%) followed patients. Genotypes C accounted for more than 68% in northern as well as southern areas, contrasting with genotype A accounting for 34% in and around the Metropolitan areas. During 24 years from 1982 to 2005, genotype A increased from 5% to 33%, while genotype B gradually decreased from 26% to 8%. Fulminant hepatitis was significantly more frequent in infection with genotype Bj (41%) than those with the other genotypes (p < 0.01). The core-promoter double mutation (T1762/A1764) and precore stop-codon mutation (A1896) were more frequent in patients with fulminant than acute self-limited hepatitis (57% versus 15% and 58% versus 10%, respectively, p < 0.01 for both). In conclusion, genotype A distributes unevenly over Japan, prevails in younger patients through sexual transmission and has increased with years. Furthermore, fulminant outcome was more frequent in patients with genotype Bj than those with the other genotypes. |
| Keywords: | Chronic hepatitis Fulminant hepatitis Hepatitis B e antigen Hepatitis B surface antigen Sexual transmission |
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