| 草问荆总生物碱对小鼠脑单胺氧化酶-B活性的影响 |
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| 引用本文： | 季宇彬,高世勇. 草问荆总生物碱对小鼠脑单胺氧化酶-B活性的影响[J]. 中草药, 2003, 34(8): 59-60 |
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| 作者姓名： | 季宇彬 高世勇 |
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| 作者单位： | 哈尔滨商业大学药物研究所,博士后科研工作站,黑龙江,哈尔滨,150076 |
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| 基金项目： | 黑龙江省科委自然科学基金资助项目 ( D0 1- 0 5) |
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| 摘 要： | 目的 研究草问荆总生物碱(TAEP)对小鼠脑单胺氧化酶—B(MAO—B)活性的影响，揭示TAEP对中枢神经系统抑制作用的机制。方法 采用紫外分光光度法测定MAO—B的活性。结果 TAEP对小鼠脑MAO—B具有明显的激活作用，并具有对抗烟肼酰胺抑制小鼠脑MAO—B活性的作用。结论 TAEP是MAO—B的激动药，有单胺代谢作用，这可能是TAEP中枢抑制作用的作用机制之一。
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| 关 键 词： | 草问荆总生物碱 单胺氧化酶—B 中枢抑制 |
| 文章编号： | 0253-2670(2003)08-0728-02 |
| 修稿时间： | 2002-10-12 |
Effect of total alkaloids in Equisetum pratense on activity of MAO-B in mice brain |
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| JI Yu bin,GAO Shi yong. Effect of total alkaloids in Equisetum pratense on activity of MAO-B in mice brain[J]. Chinese Traditional and Herbal Drugs, 2003, 34(8): 59-60 |
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| Authors: | JI Yu bin GAO Shi yong |
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| Abstract: | Object To study the effects of total alkaloids in Equisetum pratense Ehrh. (TAEP) on the activity of monoamine oxidase B (MAO B) in mice brain, to reveal the mechanism of its inhibitory action on the central nervous system (CNS). Methods The activity of MAO B was determined by UV spectrophotometry. Results TAEP can markedly activate MAO B in cerebrum and antagonise the inhibition of MAO B activity by nialamide. Conclusion TAEP is a MAO B agonist with an action for the evacuation of monoamine, this may be considered as one of the mechanisms of TAEP sedative and tranquilizing action on CNS. |
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| Keywords: | total alkaloids of Equistum pratense Ehrh. (TAEP) monoamine oxidase B (MAO B) inhibitory action on CNS |
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