| 耐亚胺培南铜绿假单胞菌耐药机制研究 |
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| 引用本文： | 姚芬,陈淑贞,钱元恕.耐亚胺培南铜绿假单胞菌耐药机制研究[J].中国热带医学,2009,9(5):909-910. |
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| 作者姓名： | 姚芬 陈淑贞 钱元恕 |
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| 作者单位： | 1. 汕头大学医学院药理教研室,广东,汕头,515041
2. 汕头大学医学院第一附属医际检验科,广东,汕头,515041 |
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| 基金项目： | 国家自然科学基金(30472109) |
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| 摘 要： | 目的了解汕头地区对亚胺培南耐药的铜绿假单胞菌（PA）的耐药情况及其机制。方法收集临床分离耐亚胺培南的PA共141株，PCR法检测包括KPC，SME，GES，PER和VEB型超广谱β内酰胺酶（ESBLs）22．PSE酶基因。结果菌株对头孢哌酮，舒巴坦的耐药率较低，未发现产KPC，SME，GES，PER和VEB型ESBLs，6株菌株产PSE酶。结论ESBLs并非汕头地区铜绿假单胞菌对亚胺培南耐药的主要原因，可能是多种机制协同作用的结果。
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| 关 键 词： | 亚胺培南 铜绿假单胞菌 耐药 |
Drug-resistant mechnism of imipenem-resistant Pseudomonas aeruginosa |
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| YAO Fen,CHEN Shuzhen,QIAN Yuan-shu.Drug-resistant mechnism of imipenem-resistant Pseudomonas aeruginosa[J].China Tropical Medicine,2009,9(5):909-910. |
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| Authors: | YAO Fen CHEN Shuzhen QIAN Yuan-shu |
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| Institution: | 1. Department of Pharmaceutics;Shantou University Medical College;Shantou 515041;Guangdong;P. R.China |
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| Abstract: | Objective To investigate the prevalence and resistant mechnism of imipenem-resistant Pseudomonas aeruginosa （PA） in Shantou area. Methods 141 clinical isolates of PA resistant to imipenem were collected. Extendedspectrum β-1aetamase （ ESBLs ） including PER, KPC, VEB, SME, GES and pseudomonas specifie enzyme（PSE） were detected by PCR. Results Cefoperazone/tazobactam showed better activity than other antibiotics. ESBLs-produeing PER,KPC, VEB,SME and GES were not detected. Six isolates were positive for PSE. Conclusions Production of ESBLs is not the principal cause of resistance to imipenem of PA in Shantou area. |
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| Keywords: | Imipenem Pseudomonas aeruginosa Resistance |
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