甲氨蝶呤明胶微球末梢栓塞效果的实验研究

本文通过肝动脉灌注的实验研究旨在证明国内首创的甲氨蝶呤明胶微球（ＭＴＸ－ｍｓ）的末梢栓塞作用，为临床介入治疗肝癌提供一种新型的化疗栓塞剂。经大白鼠肝动脉油注ＭＴＸ－ｍｓ后即刻及１０—５０天行随访肝动脉造影，显示ＭＴＸ－ｍｓ能在小动脉水平有效地阻断肝动脉血流，小剂量的微球不会引起明显的肝组织损害。ＭＴＸ－ｍｓ的降解时间约在３０～４０天左右。大白鼠肝动脉完全阻断后仍可产生侧枝循环，但多为不完全性肝动脉再通。结果揭示ＭＴＸ－ｍｓ具有明显的末梢栓塞作用。在初步的临床应用中已取得了明显的疗效。

Experimental Study of Perpheral Effect of Methotrexate Microspheres

The aim of the study is to. demonstrate Peripheral embolization effect of an initial domesttic Methotrexatemicrospheres (MTX - ms) by hepatic arterial infusion in rats, ripply a new chemoembolization agent for clinic interventional treatment of liver carcinoma. Immediatly after hepatic arterial infusion of MTX - ms in rats and 10 to 50 days later, follow up hepatic arterial angiography show that MTX - ms can effectively occlude bind flow of hepatic artery in the level of small arteries, small quantity of microspheres may not result in obvious damage of hepatic tissue. After toed ohatruction of hepatic artery collatetal circulation may still develope, but most of them are incomplete recanalization. recanalization. Results suggest that MTX - mspossess obvious Peripheral embolization effect. Primary tests in clinic treatment of liver carcinoma have achieved good results.