| THE ROLE OF P_1-PURINERGIC RECEPTORS IN THE SPINAL MECHANISMS OF ACUPUNCTURE ANALGESIA |
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| 引用本文： | Liu Changning Zhao Feiyue Zhu Lixia Department of Physiology,Institute of Acupuncture and Moxibustion,China Academy of Traditional Chinese Medicine,Beijing 100700,China. THE ROLE OF P_1-PURINERGIC RECEPTORS IN THE SPINAL MECHANISMS OF ACUPUNCTURE ANALGESIA[J]. 世界针灸杂志, 1993, 0(2) |
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| 作者姓名： | Liu Changning Zhao Feiyue Zhu Lixia Department of Physiology Institute of Acupuncture and Moxibustion China Academy of Traditional Chinese Medicine Beijing 100700 China |
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| 作者单位： | Liu Changning Zhao Feiyue Zhu Lixia Department of Physiology，Institute of Acupuncture and Moxibustion，China Academy of Traditional Chinese Medicine，Beijing 100700，China |
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| 摘 要： | It has been extensively proved that electro-acupuncture elicit analgesia in bothextensive areas and local region via supraspinal structures and spinal cord.The present investigationwas to study the role of P_1-purinergic receptors in the spinal mechanisms of weak electroacupuncture-induced analgesia.Leg withdrawal latency(LWL)to noxious radiant heat focused on the ankle regionwas used to assess the effects of acupuncture and that of P_1-purinergic(adenosine)receptor antago-nists,theophylline and caffeine on the electro-acupuncture(EA)analgesia.EA prolonged the LWLby 16.7%±20.3%,with an after-effect lasting about 15 min.Both theophylline and caffeineblocked the EA-induced prolongation of LWL in a dose-dependent manner at the doses of 1.6-16 mg/kg.These results suggest that P_1-purinegic receptor is involved in the spinal mechanisms of weak EAproduced analgesia in the rat.
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THE ROLE OF P_1-PURINERGIC RECEPTORS IN THE SPINAL MECHANISMS OF ACUPUNCTURE ANALGESIA |
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| Liu Changning Zhao Feiyue Zhu Lixia. THE ROLE OF P_1-PURINERGIC RECEPTORS IN THE SPINAL MECHANISMS OF ACUPUNCTURE ANALGESIA[J]. World Journal of Acupuncture-Moxibustion, 1993, 0(2) |
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| Authors: | Liu Changning Zhao Feiyue Zhu Lixia |
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| Affiliation: | Liu Changning Zhao Feiyue Zhu Lixia Department of Physiology,Institute of Acupuncture and Moxibustion,China Academy of Traditional Chinese Medicine,Beijing 100700,China |
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| Abstract: | |
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| Keywords: | Electro-acupuncture analgesia Pl-purinergic receptor Theophylline Caffeine |
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