环氧化酶-2蛋白表达及与胃癌生物学特征、预后的关系

目的 探讨环氧化酶-2(COX-2)蛋白表达与胃癌生物学特征及预后的关系和意义.方法 采用免疫组化法测定102例胃癌组织中COX-2蛋白的表达,并与胃癌生物特征及预后进行比较分析.结果 胃癌组织中COX-2蛋白阳性表达率67.65%,COX-2蛋白表达与胃癌生长部位、肿瘤浸润、转移、TNM分期相关(P＜0.05),与分化程度无相关(P＞0.05);COX-2蛋白阳性患者术后3年生存率明显低于阴性表达者.结论 COX-2蛋白表达与胃癌生物特征密切相关,可作为胃癌预后的一个指标.

Cyclooxygenase-2 expression and biological characteristics,prognosis in gastric carcinoma

Objective To explore expression of cyclooxygenase-2 (COX-2) and its relationship with biological characteristics and prognosis of gastric cancer. Methods The streptavidin-peroxidase immunohistochemistry was used to detect cyclooxygenase-2 expression in 102 cases of gastric cancerous tissues. All cases were followed up after operation, the discrepancy of cyclooxygenase-2 expression was compared with biological characteristics and prognosis of gastric cancer. Results The cyclooxygenase-2 expression rates in gastric carcinoma tissue was 67.65%. The level of cyclooxygenase-2 expression had significant correlations with site, lymph node metastasis, depth invaded and TNM stage of gastric carcinoma (P< 0.05). There was no correlation between cyclooxygenase-2 expression and histological differentiation of gastric carcinoma (P> 0.05). The survival analysis showed that the three-year survival rate in the cyclooxygenase-2 positive cases were lower than that in the cyclooxygenase-2 negative cases. Conclusion The level of Cox-2 expression is significantly related to the biological characteristics of gastric carcinoma and it plays an important role in prognosis of gastric carcinoma.