Interstitial pneumonitis associated with infliximab therapy without methotrexate treatment |
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Authors: | Hirofumi Taki Yukio Kawagishi Koichiro Shinoda Hiroyuki Hounoki Reina Ogawa Eiji Sugiyama Kazuyuki Tobe |
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Affiliation: | 1.First Department of Internal Medicine,University of Toyama,Toyama,Japan |
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Abstract: | Tumor necrosis factor (TNF)-α inhibitors are increasingly being used to treat rheumatoid arthritis. Infliximab (INF) is a TNF-α inhibitor that is usually used in combination with methotrexate (MTX). Interstitial lung disease (ILD) during combination therapy has been attributed to MTX rather than INF. However, INF-associated ILD without combination with MTX has recently been reported. We describe herein a case of severe ILD secondary to INF without MTX therapy. |
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