| XELOX方案一线治疗晚期或复发胃癌的临床研究 |
| |
| 引用本文： | 闵娜,何本夫,张罗生,廖洪,贾彦征.XELOX方案一线治疗晚期或复发胃癌的临床研究[J].南方医科大学学报,2010,30(3):599. |
| |
| 作者姓名： | 闵娜 何本夫 张罗生 廖洪 贾彦征 |
| |
| 作者单位： | 1. 中国人民解放军第458医院肿瘤科,广东,广州,510602
2. 中国人民解放军第421医院肿瘤科,广东,广州,510318 |
| |
| 摘 要： | 目的研究XELOX方案一线治疗局部进展期、转移性的疗效及安全性。方法经组织学证实的局部进展期、转移性或复发胃癌胃腺癌患者41例,接受XELOX方案化疗(奥沙利铂130mg/m2,静脉滴注3h,第1天,卡培他滨1000mg/m2,口服,2次/d,第1～14天,每3周重复)。每2周期后进行疗效评价。中位治疗4个周期。结果41例接受XELOX方案一线治疗的患者中,4例不可评价,CR2例,PR15例,总有效率为41.5%,SD11例,PD9例。中位疾病进展时间为6.2个月,中位生存期达到11.8个月。XELOX方案治疗中导致3-4度毒性,其中神经毒性4例,手足综合征3例,血液学毒学4例。结论XELOX方案作为一线治疗晚期或复发胃癌疗效肯定,毒副反应轻,患者耐受性好。
|
| 关 键 词： | 胃肿瘤 奥沙利铂 卡培他滨 药物疗法 |
Preliminary study of XELOX regimen as the first-line chemotherapy in advanced or recurrent gastric cancer |
| |
| MIN Na,He Ben-fu,ZHANG Luo-sheng,LIAO Hong,JIA Yan-zheng.Preliminary study of XELOX regimen as the first-line chemotherapy in advanced or recurrent gastric cancer[J].Journal of Southern Medical University,2010,30(3):599. |
| |
| Authors: | MIN Na He Ben-fu ZHANG Luo-sheng LIAO Hong JIA Yan-zheng |
| |
| Institution: | MIN Na1,He Ben-fu2,ZHANG Luo-sheng1,LIAO Hong1,JIA Yan-zheng1 1Department of Oncology,458 Hospital of PLA,Guangzhou 510602,China,2Department of Oncology,421 Hospital of PLA,Guangzhou 510318 |
| |
| Abstract: | Objective To evaluate the efficacy and toxicity of the combined therapy with oxaliplatin and capecitabine (XELOX) in patients with advanced or recurrent gastric cancer. Methods Forty-one patients with previously untreated advanced or recurrent gastric cancer received intravenous infusion of oxaliplatin at the dose of 130 mg/m2 on day 1 and oral administration of capecitabine at 1000 mg/m2 twice a day on days 1-14. The chemotherapy was repeated every 2 weeks for a median of 4 cycles. Results Two of 41 patien... |
| |
| Keywords: | stomach neoplasms oxaliplatin capecitabine drug therapy |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
| 点击此处可从《南方医科大学学报》浏览原始摘要信息 |
| 点击此处可从《南方医科大学学报》下载免费的PDF全文 |
|
