| 头孢菌素C生产工艺改进的研究Ⅴ._A大孔树脂吸附法提取头孢菌素C |
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| 引用本文： | 赵凤生,张四维,韩穗英,许文思. 头孢菌素C生产工艺改进的研究Ⅴ._A大孔树脂吸附法提取头孢菌素C[J]. 中国医药工业杂志, 1987, 0(10) |
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| 作者姓名： | 赵凤生 张四维 韩穗英 许文思 |
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| 作者单位： | 上海医药工业研究院，上海医药工业研究院，上海医药工业研究院，上海医药工业研究院 |
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| 摘 要： | 用D-I型非极性大孔吸附树脂从发酵滤液中吸附头孢菌素C,再经阴离子交换树脂进一步纯化后,加醋酸锌沉淀,在实验室研究和小规模试生产中都收到较好的效果。
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| 关 键 词： | 头孢菌素C 非极性大孔树脂 吸附 |
STUDIES ON ADSORPTION EXTRACTION OF CEPHALOSPORIN C WITH MACROPOROUS RESIN |
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| ZHAO Feng-sheng ZHANG Si-wei HAN Sui-ying XU Wen-si. STUDIES ON ADSORPTION EXTRACTION OF CEPHALOSPORIN C WITH MACROPOROUS RESIN[J]. , 1987, 0(10) |
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| Authors: | ZHAO Feng-sheng ZHANG Si-wei HAN Sui-ying XU Wen-si |
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| Affiliation: | Shanghai Institute of Pharmaceutical Industry |
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| Abstract: | D-I non-polar macroporous resin was used to adsorb cephalospo-rin C(CPC)in fermentation filtrate,and most impurities as well as 70% ofdeacetylcephalosporin C(DCPC)could be removed.The relationship between theCPC concentration of solution and the equilibrium adsorption capacity of D-Iresin corresponded with Langmuir adsorption isotherm equation.In pilot plant scale of 5t.fermentator.CPC was extracted with D-I adsorp-tion resin followed by exchanging SIPI-82 anion-exchange resin,then precipi-tated with Zn(OAC)_2.The overall yields were 70-75%,the adsorption capacityof D-I resin was about 20000u/ml. |
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| Keywords: | cephalosporin C macroporous non-polar resin adsorption |
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