| 平胃散中药物炮制前后药效学比较 |
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| 引用本文： | 张美,龚晓猛,熊瑞,崔园园,陈志敏,李文兵,胡昌江.平胃散中药物炮制前后药效学比较[J].中国实验方剂学杂志,2016,22(2):17-20. |
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| 作者姓名： | 张美 龚晓猛 熊瑞 崔园园 陈志敏 李文兵 胡昌江 |
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| 作者单位： | 成都中医药大学药学院, 成都 611137,成都中医药大学药学院, 成都 611137,成都中医药大学药学院, 成都 611137,成都中医药大学药学院, 成都 611137,成都中医药大学药学院, 成都 611137,四川新绿色药业科技发展股份有限公司, 成都 611930,成都中医药大学药学院, 成都 611137 |
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| 基金项目： | 四川省科技厅"突破性川产道地药材新品种选育"项目(2011NZ0098-12-06) |
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| 摘 要： | 目的:针对平胃散燥湿健脾、行气和胃的功效,复制相应的病理模型,将方中药物炮制前后分别组成平胃散进行药效学比较研究,探讨方中药物炮制入药的合理性。方法:将70只小鼠随机等分为正常组、模型组、阳性药物组、生品组、麸炒苍术组、炙甘草组、炮制品组,除正常组外,其余各组小鼠采用饮食不节、外湿过盛、情志不遂的综合方法复制湿困脾胃证病理模型,给药量约为0.01 m L·g~(-1);以小肠推进率、胃残留率及力竭游泳时间等为平胃散干预治疗的评价指标。结果:与正常组相比,模型组胃排空、小肠推进及抗疲劳能力极显著下降,说明造模成功。与模型组相比,各给药组均有明显的改善作用,其中阳性组与炮制品平胃散组的改善作用最显著。结论:平胃散在改善湿困脾胃证时,苍术与甘草以炮制品入药的药效更佳。
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| 关 键 词： | 平胃散 湿困脾胃证 药效学 苍术 小肠推进率 胃残留率 |
| 收稿时间： | 6/3/2015 12:00:00 AM |
Comparative Study on Pharmacodynamics of Pingwei San with Different Raw Material |
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| ZHANG Mei,GONG Xiao-meng,XIONG Rui,CUI Yuan-yuan,CHEN Zhi-min,LI Wen-bing and HU Chang-jiang.Comparative Study on Pharmacodynamics of Pingwei San with Different Raw Material[J].China Journal of Experimental Traditional Medical Formulae,2016,22(2):17-20. |
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| Authors: | ZHANG Mei GONG Xiao-meng XIONG Rui CUI Yuan-yuan CHEN Zhi-min LI Wen-bing and HU Chang-jiang |
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| Institution: | School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China,School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China,School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China,School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China,School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China,Sichuan Neo-green Pharmaceutical Co. Ltd., Chengdu 611930, China and School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China |
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| Abstract: | |
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| Keywords: | Pingwei San spleen and stomach being stranded by dampness pharmacodynamics Atractylodis Rhizoma propulsive rate of the small intestine gastric residual rate |
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