莪术瘤苗的主动免疫保护效应——莪术抗癌作用原理的探讨

用莪术油处理的L 615自血病细胞给615系小鼠进行主动免疫,能使部分免疫组小鼠耐受10⁵个L 615细胞的攻击而长期存活。对L 615的这种获得性免疫,具有肿瘤特异性,比较稳固,并可通过脾细胞悬液被动转递。这些结果,为阐明莪术抗癌作用的原理,为应用中草药制备瘤苗开展肿瘤的免疫治疗,提供了一定的实验依据。

PROPHYLACTIC EFFECT OF ACTIVE IMMUNIZATION WITH CURCUMA AROMATICA TREATED TUMOR CELLS——EXPLORATION OF MECHANISM OF ACTION OF CURCUMA AROMATICA

Immunization of inbred strain 615 mice with oleum Curcuma aromatica treated L 615 leukemic cells provided significant protection against subsequent challenge with alive L 615 leukemic cells.It was found that such acquired antitumor immunity was apparently tumor specific, rather stable and could be passively transferred to recipient L 615 mice by injection of spleen cell suspension of actively immunized mouse.Our study provided some experimental evidence for the possible mechanism of antitumor action of Curcuma aromatica and also raised the possibility of using tumor cells pretreated with Chinese herbal antitumor agents in immunotherapy of cancer.