骨髓间充质干细胞在胶质瘤治疗中的作用

背景：骨髓间充质干细胞已成为脑胶质瘤基因治疗中理想的载体细胞。目的：了解骨髓间充质干细胞在胶质瘤治疗中的研究进展及相关机制。方法：以＂bone marrow mesenchymal stem cells,mesenchymal stem cells,multipotent stem cells,treatment of glioma,gene therapy＂为检索词,检索Pubmed数据库中1990/2011-01的文献;纳入与骨髓间充质干细胞的生物特性、在胶质瘤基因治疗中作用有关的基础性、前瞻性及临床性研究。排除重复文献。结果与结论：计算机初检得到109篇文献,根据纳入排除标准,对其中30篇文献进行分析。主要阐述了骨髓间充质干细胞的生物特性,通过比较国外骨髓间质干细胞移植治疗胶质瘤的动物实验和临床研究,证实骨髓间充质干细胞作为胶质瘤基因治疗的载体,在胶质瘤治疗中具有良好的应用前景。

Effect of bone marrow msenchymal stem cells on the treatment of glioma

BACKGROUND： Bone marrow msenchymal stem cells （BMSCs） have become the ideal cell vector for the treatment of glioma.OBJECTIVE： To understand the research process and related mechanism of BMSCs in glioma therapy research.METHODS： We searched Pubmed database （1990/2011-01） with the Key words ＂bone marrow mesenchymal stem cells, mesenchymal stem cells, Multipotent stem cells,Treatment of glioma,Gene therapy＂. The basic, perspective and clinical research articles that related to the biological characteristics of the BMSCs and the effect of the BMSCs on the treatment of glioma was included. The duplicate articles were excluded. RESULTS AND CONCLUSION： More than 109 articles were screened out by computer according to inclusive and exclusive criteria, 34 documents of which were involved for analysis. Articles were described the biological characteristics of BMSCs, compared the animal experiments and the clinical research of BMSCs transplantation for treatment of glioma, and it confirmed that BMSCs as vectors for gene therapy of glioma had good development prospects in glioma treatment.