| 血红素氧合酶/一氧化碳系统在心肌缺血再灌注损伤中的保护机制 |
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| 引用本文： | 刘晨,程晓曙. 血红素氧合酶/一氧化碳系统在心肌缺血再灌注损伤中的保护机制[J]. 心血管病学进展, 2006, 27(3): 349-352 |
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| 作者姓名： | 刘晨 程晓曙 |
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| 作者单位： | 江西医学院第二附属医院心内科,江西,南昌,330006 |
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| 摘 要： | 血红素氧合酶是血红素降解的限速酶,可将血红素分解为等摩尔的胆绿素、铁和一氧化碳。血红素氧合酶/一氧化碳系统在心肌缺血再灌注中通过血管舒张、抗氧化、抗炎、抗凋亡和抗心律失常作用发挥其保护心肌和心功能的作用。并且其与一氧化氮合酶/一氧化氮系统具有相互调节作用。
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| 关 键 词： | 血红素氧合酶 一氧化碳 缺血再灌注损伤 一氧化氮合酶 一氧化氮 |
| 文章编号： | 1004-3934(2006)03-0349-04 |
| 收稿时间： | 2005-06-28 |
| 修稿时间： | 2005-10-18 |
The Cardioprotective Mechanism of the Heme Oxygenase/Carbon Monoxide System in Myocardial Ischemia-Reperfusion Injury |
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| LIU Chen,CHENG Xiao-shu. The Cardioprotective Mechanism of the Heme Oxygenase/Carbon Monoxide System in Myocardial Ischemia-Reperfusion Injury[J]. Advances in Cardiovascular Diseases, 2006, 27(3): 349-352 |
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| Authors: | LIU Chen CHENG Xiao-shu |
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| Affiliation: | Department of Cardiology, The Second Affiliated Hospital of Jiangxi Medical College, Nanchang 330006, China |
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| Abstract: | Heme oxygenase is the rate-limiting enzyme of heme catabolisation. It can break down heme into equimolar free ion, carbon monoxide and biliverdin. In myocardial ischemia-reperfusion injury, heme oxygenase can protect myocardium and cardiac function with its antioxidant, anti-inflammatory, antiapoptotic and antiarrhythmic effects. There is a coregulation between the heme oxygenase/carbon monoxide system and the nitric oxide synthase/nitric oxide system. |
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| Keywords: | heme oxygenase carbon monoxide ischemia-reperfusion injury nitric oxide synthase nitric oxide |
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