肿瘤的靶向治疗

靶向治疗是针对肿瘤细胞恶性表型的分子靶点,作用于促进肿瘤生长、存活的特异性细胞受体、信号传导等通道,实现抑制肿瘤细胞生长或促进凋亡的抗肿瘤作用。新的靶向治疗药物rituximab、伊马替尼、赫赛汀和全反式维甲酸已开始用于临床治疗,本文综述这些药物的作用机制、适应证、疗效及安全性。与传统细胞毒化疗不同,肿瘤靶向治疗具有特异性抗肿瘤作用,并且毒性明显减少。肿瘤靶向治疗令人鼓舞的初步成果为其进一步发展奠定了基础,提供了典范,开创了肿瘤化疗的新领域。

Targeted therapies for cancer

Research in the molecular basis of cancer has produced a new targeted cancer therapy directed towards to specific molecular processes that underlie the malignant phenotype. These agents target specific cancer cell receptors or signaling events that promote cancer growth and survival and result in specific anticancer effects. The review is to highlight several novel targeted agents including rituximab, imatinib, herceptin and all-trans retin-oid acid. The mechanism, indications, efficacy and safety of these targeted agents were reviewed in this article. In contrast to conventional cytotoxic chemotherapy, targeted cancer therapy possess specific anticancer effects and less toxicity. The early clinical inspiring results of these agents have built the foundation and examples for development newer generations of targeted therapies and ushered a modern field of cancer therapy.