宫颈癌与宫颈病变组织AuroraA和AuroraB表达与临床病理因素相关性分析

目的：探讨宫颈病变组织中AuroraA、B的表达与临床病理因素的相关性。方法：2010—09—012012—06—30河北医科大学第一医院门诊及住院确诊的204例宫颈病变组织，其中慢性宫颈炎40例，CINI52例，CINⅡ～Ⅲ级48例，宫颈鳞状上皮细胞癌64例。采用免疫组化法检测宫颈组织中AuroraA、B的表达，分析AuroraA、B在不同宫颈组织中表达的意义及其与临床病理特征间的关系。结果：AuroraA在慢性宫颈炎组、CINI组、CINⅡ～Ⅲ组及宫颈鳞癌组中的阳性表达率分别为2．50％（1／40）、11．54％（6／52）、62．50％（30／48）和78．69％（51／64），AuroraB分别为2．50％（1／40）、9．62％（5／52）、58．33％（28／48）和68．75％（44／64）。AuroraA、B的阳性表达率在cINⅡ～Ⅲ组及宫颈鳞癌组明显高于慢性宫颈炎组和CINI组，P〈0．001；但在宫颈鳞癌与CINⅡ～Ⅲ中的表达差异无统计学意义，P值分别为0．070和0．255。AuroraA表达与宫颈癌的临床分期（P=0．030）、淋巴转移（P一0．040）和肿瘤细胞分化程度（P=0．009）有关，AuroraB的表达与肿瘤细胞分化程度有关，P=0．007。AuroraA、B的表达呈正相关，P〈0．001。结论：AuroraA和AuroraB表达与宫颈癌的发生、发展密切相关，有望成为宫颈癌早期诊断、治疗的生物学指标。

Expressions of Aurora A and Aurora B in CIN and cervical cancer and their relationship with pathology factors

OBJECTIVE：To investigate the expression of Aurora A and Aurora B in different cervical lesion. METHODS： The expression of Aurora A,B were detected by RT PCR in 204 patients. The significance of Aurora A,B in difference cervical tissue and the relationship with clinicopathological characteristics was studied. RESULTS：1）The positive ex pression rate of Aurora A and Aurora B in the group of chronic cervicitis, CINI, CIN Ⅱ - Ⅲ and cervical cancer were 2.50%（1/40）,11. 54%（6/52）,62.50%（30/48）,78.69（51/64）;2.50%（1/40）,9.62%（5/52）,58.33%（28/48）,68.75% （44/64） respectively. The expression of Aurora A and Aurora B was higher in CIN Ⅱ --Ⅲ and cervical cancer than that in chronic cervicitis or the group of CINI （P〈0. 001）. There was no significant difference between the group of CINⅡ and the group of cervical cancer （P=0. 070;P= 0. 255）. 2）The expression of Aurora A related with clinical stage, lymph node metastasis, histological grade （P = 0. 030, P = 0. 040, P = 0. 009） ; The expression of Aurora B related with histological grade （P=0. 007）. CONCLUSION： The expression of Aurora A and B relate with the occurence and development of cervical cancer. Aurora A and Aurora B are expected to he the biomarker of early diagnosis,treatment in cervical cancer.