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Revascularization of ischemic tissues by PDGF-CC via effects on endothelial cells and their progenitors |
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| Authors: | Li Xuri Tjwa Marc Moons Lieve Fons Pierre Noel Agnes Ny Annelii Zhou Jian Min Lennartsson Johan Li Hong Luttun Aernout Pontén Annica Devy Laetitia Bouché Ann Oh Hideyasu Manderveld Ann Blacher Silvia Communi David Savi Pierre Bono Françoise Dewerchin Mieke Foidart Jean-Michel Autiero Monica Herbert Jean-Marc Collen D Heldin Carl-Henrik Eriksson Ulf Carmeliet Peter |
| Affiliation: | The Center for Transgene Technology and Gene Therapy, Flanders Interuniversitary Institute for Biotechnology (VIB), University of Leuven, Leuven, Belgium. |
| Abstract: | The angiogenic mechanism and therapeutic potential of PDGF-CC, a recently discovered member of the VEGF/PDGF superfamily, remain incompletely characterized. Here we report that PDGF-CC mobilized endothelial progenitor cells in ischemic conditions; induced differentiation of bone marrow cells into ECs; and stimulated migration of ECs. Furthermore, PDGF-CC induced the differentiation of bone marrow cells into smooth muscle cells and stimulated their growth during vessel sprouting. Moreover, delivery of PDGF-CC enhanced postischemic revascularization of the heart and limb. Modulating the activity of PDGF-CC may provide novel opportunities for treating ischemic diseases. |
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