Prognostic significance of inverse spatial QRS-T angle circadian pattern in myocardial infarction survivors |
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Authors: | Giannopoulos Georgios Dilaveris Polychronis Batchvarov Velislav Synetos Andreas Hnatkova Katerina Gatzoulis Konstantinos Malik Marek Stefanadis Christodoulos |
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Institution: | a 1st Department of Cardiology, University of Athens Medical School, Hippokration Hospital, Athens, Greece b Department of Cardiac and Vascular Sciences, St. George's University of London, London, UK |
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Abstract: | BackgroundWe investigated the predictive value of the spatial QRS-T angle (QRSTA) circadian variation in myocardial infarction (MI) patients.MethodsAnalyzing 24-hour recordings (SEER MC, GE Marquette) from 151 MI patients (age 63 ± 12.7), the QRSTA was computed in derived XYZ leads. QRS-T angle values were compared between daytime and night time. The end point was cardiac death or life-threatening ventricular arrhythmia in 1 year.ResultsOverall, QRSTA was slightly higher during the day vs. the night (91° vs. 87°, P = .005). However, 33.8% of the patients showed an inverse diurnal QRSTA variation (higher values at night), which was correlated to the outcome (P = .001, odds ratio 6.7). In multivariate analysis, after entering all factors exhibiting univariate trend towards significance, inverse QRSTA circadian pattern remained significant (P = .036).ConclusionInverse QRSTA circadian pattern was found to be associated with adverse outcome (22.4%) in MI patients, whereas a normal pattern was associated (96%) with a favorable outcome. |
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Keywords: | Myocardial infarction Risk stratification QRS-T angle Circadian variation |
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