Morphofunctional characteristic of the immune system in BALB/c and C57BL/6 mice |
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| Authors: | Trunova G V Makarova O V Diatroptov M E Bogdanova I M Mikchailova L P Abdulaeva S O |
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| Institution: | (1) Research Institute for Biological Sciences, Tokyo University of Science, 2669 Yamazaki, Noda Chiba, 278-0022, Japan;(2) Department of Medical Genomics, Graduate School of Frontier Sciences, The University of Tokyo, 5-1-5 Kashiwanoha, Kashiwa Chiba, 277-8562, Japan;(3) Department of Parasitology, Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minatoku Tokyo, 108-8639, Japan |
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| Abstract: | Inbred animals serve as an adequate model to study the role of genetic factors in adaptive, disadaptive, and pathological
processes. Morphofunctional study of the immune system was performed on intact BALB/c and C57Bl/6 mice. The structural and
functional parameters of the immune system in BALB/c and C57Bl/6 mice differ under physiological conditions. In BALB/c mice,
volume density of T zone in the spleen and production of IL-2, IL-3, IL-4, IL-10, and TNF-α were much higher than in C57Bl/6
mice. However, IL-12 production in BALB/c mice was lower than in C57Bl/6 mice. C57Bl/6 mice were characterized by higher cytostatic
activity of splenic NK cells. The observed interstrain differences are genetically determined and contribute to the type of
adaptive processes and different sensitivity of these mice to pathogenic agents. |
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