| 肝动注阿霉素及其脂质体在体内的定量分析 |
| |
| 引用本文： | 邹一愚,顾学裘,上野雅晴,堀越勇. 肝动注阿霉素及其脂质体在体内的定量分析[J]. 沈阳药科大学学报, 1992, 0(1) |
| |
| 作者姓名： | 邹一愚 顾学裘 上野雅晴 堀越勇 |
| |
| 作者单位： | 沈阳药学院制剂研究所，沈阳药学院制剂研究所，日本富山医科药科大学药剂部，日本富山医科药科大学药剂部 |
| |
| 摘 要： | 进一步研究阿霉素及其脂质体在体内的行为,需要灵敏、精确的定量分析方法,本研究建立了适用于微量阿霉素及其脂质体以及其代谢产物Adriamycinol和Adriamycinone在动物组织、血浆及尿中的高效液相分析方法。
|
| 关 键 词： | 阿霉素的体内分析 阿霉素脂质体的分析 高效液相法 |
THE QUANTITATIVE ANALYSIS OF ADRIAMYCIN AND LADM INJECTED INTO HEPATIC ARTERY IN VIVO |
| |
| Zou Yiyu Gu Xueqiu Masaharu Ueno Horikoshi Pharmceutics Research Institude,Shenyang College of Pharmacy Toyama Medical and Pharmaceutical University. THE QUANTITATIVE ANALYSIS OF ADRIAMYCIN AND LADM INJECTED INTO HEPATIC ARTERY IN VIVO[J]. Journal of Shenyang Pharmaceutical University, 1992, 0(1) |
| |
| Authors: | Zou Yiyu Gu Xueqiu Masaharu Ueno Horikoshi Pharmceutics Research Institude Shenyang College of Pharmacy Toyama Medical Pharmaceutical University |
| |
| Abstract: | An quantitative method for micro-contents of bio-samples and liposomes of Adriamycin and its metabolites was established. The concentrations of Adriamycin, Adriamycinol and Adriamycinone in animal tissues, plasma and urine were quantitated successfully by reverse-phase HPLC method, with the analytical conditions and the extraction process of bio-samples optimized. The minium possible amount was 10~(-10)g, and the recoveries of the three substances in biosamples were more than 80%. |
| |
| Keywords: | Quantitative analysis Adriamycin in vivo Quantitation Adriamycin liposome HPLC |
| 本文献已被 CNKI 等数据库收录！ |
