缬沙坦对大鼠急性心肌梗死后血清脑钠肽、内皮素-1和左室重构的影响 |
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引用本文: | 杜文涛,刘秀平,张辉,白净,袁江永,刘贵京,史素芳.缬沙坦对大鼠急性心肌梗死后血清脑钠肽、内皮素-1和左室重构的影响[J].陕西医学杂志,2013(12):1576-1578. |
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作者姓名: | 杜文涛 刘秀平 张辉 白净 袁江永 刘贵京 史素芳 |
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作者单位: | [1]河北工程大学附属医院,邯郸056002 [2]冀中能源峰峰集团总医院儿科,邯郸056002 |
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基金项目: | 河北省邯郸市科学技术研究与发展计划(1223108086-8) |
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摘 要: | 目的:探讨缬沙坦对大鼠急性心肌梗死后心室重构和血浆脑钠肽(BNP)、内皮素-1(ET-1)的影响。方法:首先制作大鼠急性心肌梗死模型,然后将手术完成后存活下来的大鼠随机分为三个组,即心肌梗死+缬沙坦组、心肌梗死组与对照组,使用缬沙坦对缬沙坦组大鼠进行治疗,检测1个月后大鼠体内的血浆脑钠肽(BNP)浓度、内皮素-1(LVESD)浓度和心室重构(LVEDD)情况。结果:与心肌梗死组相比,缬沙坦能显著缩小心室重构指标(LAD、LVESD、LVEDD)并降低了血浆BNP、ET-1水平(P<0.01),两组间差异有统计学意义。结论:使用缬沙坦治疗大鼠30d,心肌梗死的大鼠的心室重构得到抑制,血浆脑钠素、内皮素-1水平也明显降低,大鼠心功能得到显著改善。
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关 键 词: | 心肌梗塞 @缬沙坦 利钠肽 脑 内皮缩血管肽-1 |
Valsartan on acute myocardial infarction serum brain natriuretic peptide endothelin-1 and left ventricular remodeling |
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Institution: | Du Wentao, Liu Xiuping, Zhang Hui et al(Affiliated Hospital of Hebei University of Engineering Second Department (Handan 056002 )) |
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Abstract: | Objective : To observe the effects of the valsartan on serum brain natriuretic peptide(BNP), serum endothelin -1 (ET-1) and heart remodeling after acute myocardial infarction of rats. Methods :90 male wister rats were randomly divided into three groups : ① sham group (n = 30) ; ②AMI group (n = 30) ; ③ AMI + valsartan group(n=30). Rats in the AMI+valsartan group were given the valsartan. Rat's serum concentrations of BNP and ET-1 were tested at 30th day after operation while heart remodeling(LAD, LVESD, LVEDD) were measured. Re- suits :Compared with AMI Group, the blood serum levels of BNP and ET-1 in AMI+valsartan Group rats was smal- ler(P~0.05), and similarly LAD,LVESD,LVEDD in AMI+ valsartan Group rats were smaller too. Conclusions: This showed that the valsartan can lessen the increase of BNP and ET-1 blood serum levels and delay the remodeling progress of AMI at 30th day after operation. |
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Keywords: | Myocardial infarction @Valsartan Natriuretic peptide brain Endothelin-1 |
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