阻塞性睡眠呼吸暂停综合征患者肥胖与平均血小板容积的关系

目的观察阻塞性睡眠呼吸暂停综合征（OSAHS）患者中肥胖与平均血小板容积（MPV）的关系，以探讨肥胖对OS—AHS严重性以及OSAHS患者心脑血管疾病风险的影响。方法纳入147例OSAHS患者，根据睡眠呼吸暂停低通气指数（AHI）分为轻、中、重3个亚组。43例社区人群作为对照组。应用多导睡眠仪（PSG）记录患者睡眠参数，并进行身体质量指数（BMI）与MPV检测。结果：OSAHS患者各组AHI、ODI、BMI与MPV较对照组均明显升高（P〈0．05），且随OSAHS严重程度加重逐渐上升（P〈0．05），而L—SaO2与M—SaO2则呈下降趋势。OSAHS患者中肥胖组的AHI、ODI与MPV较非肥胖组明显增加（P〈0．05），L—SaO2与M—SaO2显著降低（P〈0．05），且BMI、ODI与MPV具有正相关性（P〈0．05），而L—SaO2、M—SaO，与MPV呈负相关性（P〈0．05）。结论肥胖能够加重OSAHS患者的疾病严重程度以及MPV水平，OSAHS患者的BMI与MPV水平呈正相关，提示肥胖可能增加OSAHS患者心脑血管血栓性疾病的风险。

Relation Ship Between Obesity and Mean Platelet Volume in Obstructive Sleep Apnea - hypopnea Syndrome Patients.

Objective To observe the relationship between obesity and mean platelet volume （MPV） in obstructive sleep apnea- hypopnea syndrome （OSAHS） patients, and explore the effect of obesity on the severe degree and cardiovascular risk of OSAHS. Meth- ods Totally 147 cases of OSAHS patients were included and divided into three subgroups as mild, moderate and severe according to the sleep apnea -hypopnea index （AH1）. 43 cases of community people were included as a control group. Polysomnography （PSG） was used to record the sleep parameters, and body mass index （BMI） and MPV were also measured. Results AHI, ODI, BMI and MPV in each group of OSAHS patients were significantly higher than those in control group （P 〈 O. 05 ） , and increased associated with the severity of OSAHS （P 〈0.05） , as the L - SaO2 and M - SaO2 showed a downward trend. AHI, ODI and MPV in obese group of OSAHS patients were significantly increased than those in non -obese group （P 〈0.05） , while L- SaO2 and M -SaO2decreased （P 〈 0.05 ）. In addi- tion, there was a positive correlation between BMI, ODI and MPV in OSAHS patients （P 〈 0. 05 ） , while there was a negative correlation between L - SaO2 , M - SaO2and MPV. Conclusion Obesity can increase the severity of disease and MPV level in OSAHS patients. BMI and MPV levels were positively correlated, suggesting that obesity may increase the risk of thrombotic cardiovascular disease in OSAHS pa- tients.