关节内注射药物建立骨性关节炎动物模型研究进展

骨性关节炎(Osteoarthritis,OA)是临床常见的退行性关节疾病,近年来该病发病率呈逐年上升趋势。动物实验则是研究骨性关节炎发病机制与治疗疗效的重要手段之一,而诱导动物模型的建立始终是动物实验中最重要环节之一,其中关节内注射药物是建立骨性关节炎动物模型的经典方法。实验动物的选择要遵循相关性、适当性、实用性三个原则;注射药物的选择要根据实验目的、实验对象进行;检测手段及评价方法应切合实验实际。OA动物模型的金标准至今未建立,关节内注射药物的操作规范尚未建立,期待进一步的研究。

Progress on establishment of animal model of osteoarthritis by intra articular injection

Osteoarthritis(Osteoarthritis,OA) is a common clinical degenerative joint disease with increased incidence rate in recent years. Animal experiment is one of the important ways toexplore pathogenesis and treatment of OA,while induced animal model is the most important part in animal experiment. Intra articular injection of drugs is a classical method for establishing animal model of OA. Choose of animal should follows the principle of correlation,appropriateness and practicability,injections should perform in accordance with experimental purposes and subject,detections means and evaluation methods also should corresponding to experimental reality. The gold standard of OA animal model and intra articular injections has not build,need further study.