| 气相色谱-质谱法测定炉甘石薄荷脑洗剂中2组分的含量 |
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| 引用本文： | 吴正中,余继英,何林,孙世明. 气相色谱-质谱法测定炉甘石薄荷脑洗剂中2组分的含量[J]. 中国药房, 2004, 15(12): 757-758 |
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| 作者姓名： | 吴正中 余继英 何林 孙世明 |
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| 作者单位： | 四川省医学科学院·四川省人民医院药剂科,成都市,610072 |
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| 摘 要： | 目的 :建立气相色谱 -质谱联用同时测定炉甘石薄荷脑洗剂中苯酚及薄荷脑含量的方法。方法 :以DM -5弹性石英毛细管为色谱柱 ,正辛醇为内标 ,在70℃～150℃程序升温条件下 ,选择质荷比 (m/z)为56、94、71的离子碎片峰分别对苯酚和薄荷脑进行检测。结果 :苯酚、薄荷脑的检测浓度线性范围分别为1 092～21 840μg/ml(r=0 9998)、1 194～9 552μg/ml(r=0 9999) ;平均回收率分别为100 2 % (RSD=1 34 % )、100 4 % (RSD=0 74 % )。结论 :本法可用于炉甘石薄荷脑洗剂的含量测定和质量控制 ,且快速、准确、特异性高、重现性好。
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| 关 键 词： | 气相色谱-质谱法 苯酚 薄荷脑 含量 |
| 文章编号： | 1001-0408(2004)12-0757-02 |
| 修稿时间： | 2003-12-18 |
Determination of Two Ingredients in Calamine and Menthol Lotion by GC- MS |
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| WU Zhengzhong,YU Jiying,HE Lin,SUN Shiming. Determination of Two Ingredients in Calamine and Menthol Lotion by GC- MS[J]. China Pharmacy, 2004, 15(12): 757-758 |
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| Authors: | WU Zhengzhong YU Jiying HE Lin SUN Shiming |
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| Abstract: | OBJECTIVE:To establish a GC-MS assay for determination of the contents of phenol and menthol in calamine and menthol lotion.METHODS:Using DM-5elastic quartz capillary as separation column,I-octanol as internal standard,phenol and menthol were detected separately under the70℃～150℃step-up hyperthermic condition to select the ion fragment peaks with M/Z of94and71.RESULTS:Phenol and menthol were good linear within1.092～21.840μg/ml(r=0.9998)and1.194～9.552μg/ml(r=0.9999).Recoveries were100.2%(RSD=1.34%)and100.4%(RSD=0.74%)respectiveˉly.CONCLUSION:The method is quick and accurate with highly repeatability and specificity and it is adequate for contents determination and quality control for this preparation. |
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| Keywords: | GC-MS phenol menthol content |
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