Conservative therapy of frequency,urgency and urge incontinence: A double-blind clinical trial of flavoxate hydrochloride,exybutinin chloride,emepronium bromide and placebo |
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Authors: | A. G. M. Zeegers H. Kiesswetter A. E. J. L. Kramer U. Jonas |
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Affiliation: | (1) Department of Urology, Academic Hospital Leiden, Rijnsburgerweg 10, NL-2333 AA Leiden, The Netherlands;(2) Department of Urology, Wilhelminenspital der Stadt Wien, Vienna, Austria |
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Abstract: | Summary Sixty unselected patients from two centers (40+20) with complaints indicating detrusor overactivity or hypersensitivity entered a prospective double-blind cross-over trial to test the efficacy of drug treatment. Two active drugs and a placebo were taken at random during consecutive 3-week periods. The active drugs used were emepronium bromide, which was given to all patients, and flavoxate hydrochloride (given to 30) and oxybutinin chloride (given to the other 30 patients). Anamnestic and cystometric data were recorded after each treatment period and compared with the values on admission. Effect was scored by patient and physician separately. Serious side effects were noted during the administration of emepronium bromide, while flavoxate hydrochloride had even fewer and milder side effects than placebo. Although no objective significant changes could be demonstrated, the total scoring results of oxybutinin chloride were better than that of the three other treatments. The other two active drugs scored no better than placebo. |
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