甲亢患者人格特征及与脑血流灌注相关分析

目的：分析甲亢患者人格特征及与脑功能变化的关系。方法：35例甲亢患者纳入研究,男性9例,女性26例;平均年龄（38.74±10.57）岁;病程为1.5个月至9年。短病程组15例（病程小于等于6个月）,长病程组20例（病程大于6个月）。正常对照者28例,男性8例,女性20例;平均年龄（35.8±9.41）岁。所有患者及正常对照均行静息~（99）Tc~m-ECD SPECT脑血流灌注显像。应用艾森克人格问卷（EPQ）分析人格特征;7例患者经治疗甲功正常后再次行人格特征分析及脑血流灌注显像。结果：甲亢患者具有高神经质及精神质的人格特征（P〈0.05）;不同病程患者人格特征无显著差异;治疗后患者人格特征评分无显著变化（P〉0.05）,但神经质维度N评分有明显减低趋势。甲亢患者高神经质评分与丘脑、海马旁回、后内嗅皮层、苍白球、乳头体血流灌注呈显著负相关（P〈0.05）。结论：甲亢患者具有高精神质及神经质的个性特征,可能与其本身具有的不稳定个性特征及疾病导致的局部脑血流灌注减低、脑功能异常有关。

The Study of Personality Traits and its Relationship to Cerebral Blood Flow Perfusion in Patients with Hyperthyroidism

Objective：To analyze the personality traits of patients with hyperthyroidism and its possible relationship to cerebral blood flow.Methods：Thirty-five patients（9 males,26 females;38.74±10.57 ys） with hyperthyroidism were enrolled,who were divided into short duration group（equal or less 6 months,n=15） and long duration group（longer than 6 months,n = 20）. Twenty-eight healthy volunteers（males 8,females 20;35.8±9.41 ys） were included as controls.SPECT cerebral blood flow perfusion imaging was performed at rest after 99Tcm- ECD injection.The personality traits of all patients and controls were assessed with EPQ questionnaire.Results：Hypoperfusion in limb system and frontal lobes were shown in hyperthyroidism patients. Hyperthyroidism patients had higher neuroticism and psychoticism scores,which had not changed significantly after euthyroid. The scores of neuroticism were correlated negatively with rCBF in thalamus,parahippocampal gyrus,posterior entorhinal cortex,globus pallidus and mammilary body（P〈0.05）.Conclusions：Patients with hyperthyroidism have significant neuroticism and psychoticism characteristics,which might be related to impaired cerebral blood flow in specific region,besides their specific personality traits.