Polymorphisms in inflammasome' genes and susceptibility to HIV-1 infection |
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| Authors: | Pontillo Alessandra Oshiro Telma M Girardelli Martina Kamada Anselmo J Crovella Sergio Duarte Alberto J S |
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| Affiliation: | Laboratory of Medical Investigation in Dermatology and Immunodeficiency, Faculty of Medicine, University of Sao Paulo, Sao Paulo, Brazil. pontillo.a@gmail.com |
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| Abstract: | The involvement of inflammasome genes in the susceptibility to HIV-1 infection was investigated. Twelve single nucleotide polymorphisms within NLRP1, NLRP3, NLRC4, CARD8, CASP1, and IL1B genes were analyzed in 150 HIV-1-infected Brazilian subjects and 158 healthy controls. The 2 polymorphisms rs10754558 in NLRP3 and rs1143634 in IL1B were significantly associated to the HIV-1 infection. These findings supported the previously hypothesized involvement of NALP3-inflammasome in HIV-1 pathogenesis, underlining once more the key role of inflammation and innate immunity in the susceptibility to HIV-1 infection. |
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