Paraneoplastic encephalitis associated with myasthenia gravis and malignant thymoma |
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Authors: | Miyazaki Yu Hirayama Masaaki Watanabe Hirohisa Usami Noriyasu Yokoi Kohei Watanabe Osamu Sobue Gen |
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Affiliation: | Department of Neurology, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya 466-8550, Japan. |
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Abstract: | We present a patient with type B2 thymoma (World Health Organization Thymoma Classification) with the complications of anti-muscle acetylcholine receptor antibody-positive myasthenia gravis and anti-voltage-gated potassium channel antibodies associated with paraneoplastic encephalitis. A timing difference between the onset of these neurological disorders and a dissociation of clinical symptoms was observed during the disease. This report alerts clinicians that long-term follow-up is needed where patients have a residual thymoma and attention should be paid to other concomitant autoimmune disorders. |
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