Revisiting histopathologic findings in Goltz syndrome |
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Authors: | Christine J. Ko Richard J. Antaya Amanda Zubek Brittany Craiglow William Damsky Anjela Galan Jennifer M. McNiff |
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Affiliation: | 1. Department of Dermatology, Yale University, New Haven, CT;2. Department of Pathology, Yale University, New Haven, CT, USA |
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Abstract: | Goltz syndrome (focal dermal hypoplasia) is an X‐linked dominant disorder that is classically associated with yellowish papules representing fat herniation (superficial adipocytes). We report a series of three cases, with clinicopathologic correlation of biopsies from Blaschkoid streaks. A range of histopathologic features, including some underreported findings (increased papillary dermal blood vessels, decreased thickness of the dermis, and adipocytes high in the dermis), are reproducible and can strongly point to the correct diagnosis of Goltz syndrome. |
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Keywords: | Blaschkoid focal dermal hypoplasia Goltz syndrome PORCN telangiectasia |
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