In vivo vibrometry inside the apex of the mouse cochlea using spectral domain optical coherence tomography |
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| Authors: | Simon S. Gao Patrick D. Raphael Rosalie Wang Jesung Park Anping Xia Brian E. Applegate John S. Oghalai |
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| Affiliation: | 1Department of Otolaryngology-Head and Neck Surgery, Stanford University, 801 Welch Road, Stanford, CA 94305, USA;2Department of Bioengineering, Rice University, 6100 Main Street, Houston, TX 77005, USA;3Department of Biomedical Engineering, Texas A&M University, 337 Zachry Engineering Center, 3120 TAMU, College Station, TX 77843, USA |
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| Abstract: | Sound transduction within the auditory portion of the inner ear, the cochlea, is a complex nonlinear process. The study of cochlear mechanics in large rodents has provided important insights into cochlear function. However, technological and experimental limitations have restricted studies in mice due to their smaller cochlea. These challenges are important to overcome because of the wide variety of transgenic mouse strains with hearing loss mutations that are available for study. To accomplish this goal, we used spectral domain optical coherence tomography to visualize and measure sound-induced vibrations of intracochlear tissues. We present, to our knowledge, the first vibration measurements from the apex of an unopened mouse cochlea.OCIS codes: (170.4500) Optical coherence tomography, (170.4940) Otolaryngology |
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